Selective Mono Bromination of 1,4-Dihydropyridines

Authors

  • Adeleh Moshtaghi Zenouz Organic Synthesis Research Lab., Faculty of Chemistry, Tabriz University, Zip code 51664, Tabriz, I.R. IRAN
  • Yousef Rastgar Mirzaei Organic Synthesis Research Lab., Faculty of Chemistry, Tabriz University, Zip code 51664, Tabriz, I.R. IRAN
Abstract:

2-monobromomethyl 1,4-dihydropyridines is selectively synthesized by bromination of the parent compound by 1.1 equivalents of pyridinium bromide perbromide in dichloromethane/pyridine at -20 °C. The same reagent in dichloromethane at 0 °C produce the 2,6-bis(bromomethyl) 1,4-dihydropyridines.

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Journal title

volume 16  issue 1

pages  29- 32

publication date 1997-06-01

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